Marco Santucci started his work in the Italian comics field, working on the miniseries "Nembo" for Phoenix Publishing and the sci-fi series "Samuel Sand" for Star Comics. In 1998, he started his long collaboration with Marco Bianchini of Sergio Bonelli Publishing when he drew (as penciler) his first series "Mister No". In the meanwhile he has been worked on the screenplay of "Termite Bianca" for the Italian publisher Vittorio Pavesio Productions. At the end of 2005, Marco joined the staff of the most famous Bonelli's series, Tex, which has always been inked by Bianchini. On 2008 Marco started his first work for Marvel comics, the miniseries "Secret Invasion: Spider-man - A brand new day".